Jennifer Jason Leigh
| Year | Movie | Function | Role |
| 2010 | Greenberg | writer | |
| 2010 | Greenberg | actor | |
| 2010 | Greenberg | actor | Beth |
| 2008 | Synechdoche, New York | actor | Maria |
| 2007 | Margot at the Wedding | actor | Pauline |
| 2005 | The Jacket | actor | Dr. Beth Lorenson |
| 2004 | Childstar | actor | Suzanne |
| 2004 | Palindromes | actor | 'Mark' Aviva |
| 2004 | The Machinist | actor | Stevie |
| 2003 | In the Cut | actor | Pauline |
| 2003 | Sex at 24 Frames Per Second | actor | Stacy Hamilton (archive footage) |
| 2002 | Searching for Debra Winger | actor | Herself (uncredited) |
| 2002 | Road to Perdition | actor | Annie Sullivan |
| 2002 | Hey Arnold The Movie | actor | Bridget (voice) |
| 2001 | The Quickie | actor | Lisa |
| 2001 | The Anniversary Party | director | |
| 2001 | The Anniversary Party | writer | |
| 2001 | The Anniversary Party | actor | Sally Therrian |
| 2001 | The Man Who Wasn't There | actor | Female inmate (uncredited) |
| 2000 | The King Is Alive | actor | Gina |
| 2000 | Playboy: The Complete Anna Nicole Smith | actor | Herself (archive footage) |
| 2000 | Playboy: The Complete Anna Nicole Smith | actor | Herself (archive footage) |
| 1999 | Spawn 3: The Ultimate Battle | actor | Lilly (voice) |
| 1999 | eXistenZ | actor | Allegra Geller |
| 1999 | Todd McFarlane's Spawn | actor | Lilly (2 episodes, 1999) |
| 1998 | Thanks of a Grateful Nation | actor | Teri Small |
| 1998 | The Love Letter | actor | Elizabeth Whitcomb |
| 1997 | Washington Square | actor | Catherine Sloper |
| 1997 | A Thousand Acres | actor | Caroline Cook |
| 1996 | Kansas City | actor | Blondie O'Hara |
| 1995 | Georgia | actor | Sadie Flood |
| 1995 | Dolores Claiborne | actor | Selena St. George |
| 1994 | Mrs. Parker and the Vicious Circle | actor | Dorothy Parker |
| 1994 | The Hudsucker Proxy | actor | Amy Archer |
| 1993 | Short Cuts | actor | Lois Kaiser |
| 1992 | Single White Female | actor | Hedra 'Hedy' Carlson |
| 1991 | Rush | actor | Kristen Cates |
| 1991 | Crooked Hearts | actor | Marriet Hoffman |
| 1991 | Backdraft | actor | Jennifer Vaitkus |
| 1990 | Miami Blues | actor | Susie Waggoner |
| 1989 | Last Exit to Brooklyn | actor | Tralala |
| 1988 | Heart of Midnight | actor | Carol |
| 1987 | Sister, Sister | actor | Lucy Bonnard |
| 1986 | The Hitcher | actor | Nash |
| 1985 | Flesh+Blood | actor | Agnes |
| 1984 | Grandview, U.S.A. | actor | Candy Webster |
| 1983 | Easy Money | actor | Allison Capuletti |
| 1982 | Fast Times at Ridgemont High | actor | Stacy Hamilton |
| 1982 | Wrong Is Right | actor | Young Girl on Reality Program |
| 1981 | Eyes of a Stranger | actor | Tracy Harris |