John Lithgow
| Year | Movie | Function | Role |
| 2011 | Lives of the Saints | actor | |
| 2011 | New Year's Eve | actor | Mr. Cox |
| 2011 | Rise of the Apes | actor | |
| 2010 | Leap Year | actor | Jim |
| 2010 | Leap Year | actor | Jack Brady |
| 2009 | The National Parks: America's Best Idea - EPISODE SIX: 1946?1980 The Morning of Creation | actor | (voice) |
| 2009 | The National Parks: America's Best Idea - EPISODE THREE: 1915?1919 The Empire of Grandeur | actor | (voice) |
| 2009 | The National Parks: America's Best Idea | actor | (2 episodes, 2009) |
| 2009 | Confessions of a Shopaholic | actor | Edgar West |
| 2008 | Classical Baby: The Poetry Show | actor | |
| 2007 | ShowBusiness: The Road to Broadway | actor | Himself (uncredited) |
| 2006 | Dreamgirls | actor | Jerry Harris |
| 2005 | E=mc˛ | actor | Narrator (voice: English version) |
| 2005 | How I Met Your Mother | actor | Jerry Whitaker (2 episodes, 2011) |
| 2004 | Kinsey | actor | Alfred Seguine Kinsey |
| 2004 | The Life and Death of Peter Sellers | actor | Blake Edwards |
| 2003 | Shrek 4-D | actor | Ghost of Farquaad (voice) |
| 2002 | Orange County | actor | Bud Brumder |
| 2001 | Shrek | actor | Lord Farquaad (voice) |
| 2001 | Shrek In The Swamp Karaoke Dance Party | actor | Lord Farquaad (singing voice) |
| 2000 | Rugrats in Paris | actor | Jean-Claude (voice) |
| 2000 | Don Quixote | actor | Don Quixote de La Mancha / Alonso Quixano |
| 1998 | A Civil Action | actor | Judge Walter J. Skinner |
| 1998 | Homegrown | actor | Malcolm / Robert Stockman |
| 1998 | Johnny Skidmarks | actor | Sergeant Larry Skovik |
| 1996 | Hollow Point | actor | Thomas Livingston |
| 1994 | Silent Fall | actor | Dr. Rene Harlinger |
| 1994 | Princess Caraboo | actor | Professor Wilkinson |
| 1994 | A Good Man in Africa | actor | Arthur Fanshawe, British High Commissioner |
| 1993 | The Pelican Brief | actor | Smith Keen |
| 1993 | Cliffhanger | actor | Qualen |
| 1992 | Raising Cain | actor | Carter / Cain / Dr. Nix / Josh / Margo |
| 1991 | At Play in the Fields of the Lord | actor | Leslie Huben |
| 1991 | Ricochet | actor | Blake |
| 1991 | L.A. Story | actor | Harry Zell (scenes deleted) |
| 1990 | Memphis Belle | actor | Lt.Col. Bruce Derringer |
| 1988 | Distant Thunder | actor | Mark Lambert |
| 1987 | Harry and the Hendersons | actor | George Henderson |
| 1986 | Resting Place | actor | Maj. Kendall Laird |
| 1986 | Mesmerized | actor | Oliver Thompson |
| 1985 | Santa Claus: The Movie | actor | B.Z. |
| 1984 | 2010: The Year We Make Contact | actor | Dr. Walter Curnow |
| 1984 | The Adventures of Buckaroo Banzai Across the 8th Dimension | actor | Lord John Whorfin / Dr. Emilio Lizardo |
| 1984 | Footloose | actor | Reverend Shaw Moore |
| 1983 | Terms of Endearment | actor | Sam Burns |
| 1983 | The Day After | actor | Joe Huxley |
| 1983 | Twilight Zone: The Movie | actor | John Valentine (Segment #4) |
| 1982 | The World According to Garp | actor | Roberta Muldoon |
| 1982 | I'm Dancing as Fast as I Can | actor | Mr. Brunner |
| 1981 | Blow Out | actor | Burke |
| 1979 | All That Jazz | actor | Lucas Sergeant |
| 1978 | The Big Fix | actor | Sam Sebastian |
| 1976 | Obsession | actor | Robert Lasalle |